MOLES classification
Pronunciation: MOLES classification
Also written as: MOLES — Margin, Orange pigment, Large size, Enlargement, Subretinal fluid
Scoring system using Margin, Orange pigment, Large size, Enlargement, and Subretinal fluid to assess choroidal nevus malignant potential.
Full Definition
MOLES classification is a clinical scoring system developed to assess the risk of malignant transformation in choroidal nevi. The acronym represents five key risk factors: Margin (irregular or indistinct), Orange pigment (lipofuscin deposits), Large size (>5mm diameter), Enlargement (documented growth), and Subretinal fluid. Each factor contributes points to a total score that correlates with transformation risk. Nevi with higher MOLES scores require closer monitoring and may warrant prophylactic treatment. This classification system helps standardize the assessment of choroidal nevi and guides clinical decision-making regarding observation intervals and intervention thresholds.
Usage
Usage note: Specifically for choroidal nevus risk assessment; not applicable to other lesions.
In Context
- "The choroidal nevus scored 3 points on the MOLES classification, indicating increased malignant potential." — Ophthalmology consultation note
- "MOLES classification helps determine appropriate follow-up intervals for choroidal nevi." — Clinical practice guideline