tumor seeding
Inadvertent dissemination of cancer cells during biopsy or surgical manipulation of intraocular tumors.
Full Definition
Tumor seeding refers to the spread of malignant cells along needle tracks, surgical sites, or into adjacent tissues following biopsy or incomplete resection of intraocular tumors. In ocular oncology, this complication is of particular concern with uveal melanomas and retinoblastomas, where biopsy procedures can potentially cause extraocular extension or orbital seeding. Historical cases of choroidal melanoma seeding following fine needle aspiration biopsy led to reluctance in performing intraocular biopsies. Modern techniques using small-gauge needles and careful surgical planning have reduced but not eliminated this risk. The phenomenon necessitates careful consideration of diagnostic approaches and may influence treatment sequencing.
Usage
Usage note: Emphasize iatrogenic nature to distinguish from spontaneous tumor spread.
In Context
- "The risk of tumor seeding was discussed prior to performing fine needle aspiration biopsy." — Informed consent documentation
- "Orbital tumor seeding was suspected based on the needle track enhancement seen on post-biopsy MRI." — Imaging interpretation