Pseudoexfoliation syndrome
Also written as: PXS — Pseudoexfoliation syndrome
Age-related disorder characterized by deposition of fibrillar material on ocular structures, commonly causing secondary glaucoma.
Full Definition
Pseudoexfoliation syndrome (PXS) is a systemic age-related disorder involving the deposition of abnormal fibrillar material on the lens capsule, iris, and other anterior segment structures. The condition is characterized by a central clear zone on the lens surface surrounded by a granular deposit, with peripheral flaking of material. PXS significantly increases the risk of secondary glaucoma due to trabecular meshwork clogging and is associated with surgical complications including weak zonules and capsular fragility during cataract surgery. The syndrome shows geographic and genetic predisposition, with higher prevalence in Scandinavian and Mediterranean populations.
Usage
Usage note: Distinguished from 'true exfoliation' which involves lens capsule delamination from heat or infrared exposure.
In Context
- "The patient exhibited classic signs of pseudoexfoliation syndrome with central clearing and peripheral deposits on the lens capsule." — Clinical examination
- "Cataract surgery in pseudoexfoliation syndrome requires careful attention to zonular integrity and capsular support." — Surgical planning