total lesion glycolysis
Also written as: TLG
A composite PET parameter combining metabolic tumor volume and average SUV to quantify total tumor metabolic activity.
Full Definition
Total lesion glycolysis (TLG) is a volumetric PET parameter that represents the overall metabolic burden of a tumor by combining both the volume of metabolically active tissue (MTV) and its average metabolic activity (SUVmean). TLG is calculated as the product of metabolic tumor volume and SUVmean, providing a measure that incorporates both tumor size and metabolic intensity. This composite parameter may be more prognostically significant than individual SUV measurements, as it reflects total tumor glucose consumption. TLG is increasingly used for staging, prognosis assessment, and treatment response evaluation in various malignancies.
Usage
Usage note: Abbreviate as TLG; emphasize that it combines volume and intensity measurements
In Context
- "Baseline total lesion glycolysis of 125 predicted aggressive disease behavior." — Prognostic study report
- "TLG reduction exceeded 80% following three cycles of chemotherapy." — Treatment response assessment