Complete Pathologic Response
Also written as: pCR — Complete Pathologic Response
Absence of viable cancer cells in the surgical specimen after neoadjuvant therapy.
Full Definition
Complete pathologic response (pCR) represents the complete elimination of viable tumor cells from the primary tumor site and, in some definitions, regional lymph nodes following neoadjuvant chemotherapy, radiation, or combined therapy. This finding is associated with improved long-term survival in many tumor types, particularly breast cancer, rectal cancer, and esophageal cancer. The definition may vary by tumor type - some require absence of invasive cancer only, while others require elimination of both invasive and in-situ components. Achievement of pCR often influences adjuvant therapy decisions and long-term surveillance strategies.
Usage
Usage note: Definitions may vary by tumor type. Always specify whether lymph nodes are included in the assessment.
In Context
- "Final pathology revealed complete pathologic response with no residual invasive carcinoma identified." — pathology report
- "The patient achieved complete pathologic response after neoadjuvant chemotherapy, indicating excellent treatment sensitivity." — oncology follow-up note