tumor bed sampling
The practice of obtaining tissue specimens from the surgical cavity after tumor removal to assess for residual disease.
Full Definition
Tumor bed sampling involves the systematic collection of tissue specimens from the walls and base of the surgical cavity following tumor excision. This technique helps identify microscopic residual disease that may not be visible to the surgeon and guides decisions about the adequacy of resection. Sampling is typically performed using electrocautery or biopsy forceps, with specimens sent for frozen section analysis or permanent histopathology. The practice is particularly important in cases where achieving negative margins is technically challenging or when tumor characteristics suggest high risk of residual disease.
Usage
Usage note: Different from margin assessment; focuses on the cavity itself rather than the specimen edges.
In Context
- "Tumor bed sampling revealed microscopic residual carcinoma requiring additional resection." — Pathology report
- "Systematic tumor bed sampling was performed from all four quadrants of the resection cavity." — Operative report