complete response
Also written as: CR — Complete Response
Disappearance of all detectable disease following cancer treatment, as defined by specific imaging and clinical criteria.
Full Definition
Complete response (CR) represents the best possible outcome following cancer treatment, indicating that no evidence of disease can be detected using available diagnostic methods. This determination is based on imaging studies, physical examination, and relevant biomarkers according to established response criteria such as RECIST. While CR indicates excellent treatment response, it does not guarantee cure, as microscopic disease may remain undetectable. Documentation of complete response is critical for clinical trials, treatment planning, and patient monitoring. The criteria for CR may vary depending on cancer type and the specific response evaluation system used.
Usage
Usage note: Use 'complete response' in full on first mention, then 'CR' is acceptable; distinguish from 'complete remission' which may have different clinical implications.
In Context
- "Imaging at 12 weeks demonstrated complete response to immunotherapy." — Radiology report
- "The study's primary endpoint was complete response rate at 6 months." — Clinical trial documentation