COSMIC
Also written as: COSMIC — Catalogue of Somatic Mutations in Cancer
The Catalogue of Somatic Mutations in Cancer, a comprehensive database of cancer-associated genetic variants.
Full Definition
COSMIC serves as the world's largest source of expert-curated somatic mutation information relating to human cancers. Maintained by the Wellcome Sanger Institute, it provides detailed information about mutations, their functional impact, and clinical significance. In oncology informatics workflows, COSMIC identifiers are frequently referenced in variant annotation pipelines and molecular tumor board discussions. Editorial staff should recognize COSMIC IDs in clinical documentation and research manuscripts.
Usage
Usage note: Always written in all capitals; include full form on first mention in formal documents.
In Context
- "The variant annotation pipeline cross-referenced the mutation against COSMIC to determine its pathogenicity score." — Bioinformatics workflow documentation
- "According to COSMIC database entries, this particular BRAF mutation has been observed in 847 melanoma samples." — Molecular tumor board report