immune checkpoint inhibitor
Also written as: ICI — immune checkpoint inhibitor
Therapeutic agents that block regulatory pathways preventing immune system activation against cancer cells.
Full Definition
Immune checkpoint inhibitors represent a class of immunotherapy drugs that target checkpoint proteins like PD-1, PD-L1, and CTLA-4 to enhance T-cell activation against tumors. These agents have revolutionized cancer treatment across multiple tumor types. In oncology informatics, checkpoint inhibitor therapy requires specialized data collection for immune-related adverse events, response pattern monitoring, and biomarker correlation analysis. Clinical decision support systems incorporate checkpoint inhibitor eligibility criteria and safety monitoring protocols.
Usage
Usage note: Hyphenate compound modifiers; use singular form even when referring to the drug class.
In Context
- "The patient experienced grade 3 colitis after six cycles of immune checkpoint inhibitor therapy." — Oncology clinic progress note
- "Biomarker analysis revealed high tumor mutational burden, supporting immune checkpoint inhibitor treatment selection." — Molecular tumor board recommendation