OncoKB

Full Definition

OncoKB provides evidence-based annotations for cancer variants, assigning therapeutic implications through a structured evidence hierarchy. Developed by Memorial Sloan Kettering Cancer Center, it categorizes variants into actionability levels from Level 1 (FDA-approved therapies) to Level 4 (biological evidence). The platform integrates with clinical decision support systems and variant interpretation workflows. Editorial teams encounter OncoKB annotations in molecular pathology reports and precision oncology consultations.

Usage

Usage note: Capitalize as proper noun; avoid hyphenation between 'Onco' and 'KB'.

In Context

• "The molecular pathologist assigned an OncoKB Level 1 annotation to the BRAF V600E mutation, indicating FDA-approved targeted therapy options." — Molecular pathology report
• "Our variant interpretation pipeline automatically queries OncoKB for therapeutic implications of detected alterations." — Bioinformatics system documentation