patient-derived xenograft database
Repository containing characterized cancer models derived from patient tumors, used for drug testing and biomarker discovery in precision oncology research.
Full Definition
A patient-derived xenograft (PDX) database is a specialized repository that catalogs and characterizes cancer models created by transplanting patient tumor tissue into immunocompromised mice. These databases contain detailed information about each PDX model including the original patient's clinical characteristics, tumor molecular profile, treatment history, and outcomes. The database tracks the model's growth characteristics, drug sensitivity profiles, genomic stability, and correlation with patient response patterns. PDX databases are valuable resources for precision oncology research, enabling researchers to identify models that represent specific cancer subtypes, test novel therapeutic combinations, and validate biomarkers for treatment selection. Many databases are shared resources that support collaborative research across institutions.
Usage
Usage note: Specialized research resource; PDX is commonly used as abbreviation for patient-derived xenograft.
In Context
- "Researchers queried the patient-derived xenograft database to identify models suitable for testing the new targeted therapy." — Preclinical research protocol
- "The PDX database enabled correlation analysis between model drug sensitivity and patient treatment outcomes." — Translational research manuscript