adamantinoma
Pronunciation: ad-uh-man-ti-NO-mah
A rare primary bone tumor typically arising in the tibial diaphysis with epithelial and mesenchymal components.
Full Definition
Adamantinoma is a rare malignant bone tumor that predominantly affects the tibia, accounting for less than 1% of all primary bone tumors. It is characterized by a biphasic pattern containing both epithelial and mesenchymal elements, often presenting with a distinctive multinodular appearance on imaging. The tumor typically occurs in adults between 20-50 years of age and has a propensity for local recurrence if inadequately excised. Complete surgical excision with wide margins is the treatment of choice, as the tumor is generally resistant to chemotherapy and radiation therapy.
Usage
Usage note: Often confused with osteofibrous dysplasia; careful histological examination is required for differentiation.
In Context
- "The MRI revealed a lobulated lesion in the tibial diaphysis consistent with adamantinoma." — Radiology report
- "Histopathological examination confirmed the diagnosis of adamantinoma with characteristic epithelial islands." — Pathology report