chondrosarcoma

Full Definition

Chondrosarcoma is a malignant tumor that produces cartilaginous matrix, representing the second most common primary bone sarcoma after osteosarcoma. It typically affects older adults and commonly arises in the pelvis, proximal femur, and ribs. Chondrosarcomas are graded from I to III based on cellularity, nuclear size, and mitotic activity. Low-grade tumors are generally resistant to chemotherapy and radiation, making complete surgical excision the mainstay of treatment.

Usage

Usage note: Always specify grade (I-III) when documenting chondrosarcoma cases.

In Context

• "Grade II chondrosarcoma of the pelvis requires wide surgical excision with negative margins." — Surgical report
• "The distinction between enchondroma and low-grade chondrosarcoma can be challenging." — Radiology report