Professional
Technical
IVT
Ewing sarcoma
Pronunciation: YOO-ing sar-KOH-mah
Aggressive round cell sarcoma of bone and soft tissue, typically affecting children and young adults.
Full Definition
Ewing sarcoma is a highly aggressive malignant tumor characterized by small round blue cells, most commonly arising in the diaphyses of long bones, pelvis, and ribs. It belongs to the Ewing sarcoma family of tumors (ESFT) and is characterized by specific chromosomal translocations, most commonly t(11;22). The tumor shows a propensity for early metastasis to lungs and bones. Treatment involves multimodal therapy including chemotherapy, surgery, and/or radiation therapy.
Usage
Usage note: Named after James Ewing; capitalize the E in Ewing when referring to the specific tumor type.
In Context
- "The Ewing sarcoma demonstrated the characteristic t(11;22) translocation on molecular testing." — Pathology report
- "Pelvic Ewing sarcoma often presents diagnostic challenges due to its deep location." — Case presentation
Also known as
ESFT
Ewing sarcoma family of tumors
Don't confuse with
osteosarcoma
lymphoma
metastatic small cell carcinoma