fibrous dysplasia
Pronunciation: FY-brus dis-PLAY-zhah
Also written as: FD — Fibrous Dysplasia
A benign bone disorder where normal bone is replaced by fibrous tissue containing immature woven bone, creating characteristic ground-glass appearance.
Full Definition
Fibrous dysplasia is a benign skeletal disorder characterized by the replacement of normal bone and marrow with fibrous tissue containing irregularly arranged, immature woven bone trabeculae. The condition results from mutations affecting bone formation and presents with characteristic ground-glass radiographic appearance and progressive bone deformity. Fibrous dysplasia may be monostotic (affecting single bone) or polyostotic (affecting multiple bones), with the latter sometimes associated with McCune-Albright syndrome. While generally benign, there is a small risk of malignant transformation to sarcoma, particularly in polyostotic disease or after radiation therapy. Treatment focuses on managing symptoms, correcting deformities, and preventing complications.
Usage
Usage note: Hyphenate when used as a compound modifier.
In Context
- "The ground-glass appearance and expansion of the proximal femur were characteristic of fibrous dysplasia." — Radiology report
- "Polyostotic fibrous dysplasia required multidisciplinary management including endocrine evaluation." — Treatment planning conference