giant cell tumor
Also written as: GCT — giant cell tumor
Locally aggressive benign bone tumor characterized by multinucleated giant cells.
Full Definition
Giant cell tumor (GCT) of bone is a locally aggressive but typically benign neoplasm characterized by the presence of multinucleated giant cells and mononuclear stromal cells. It most commonly affects the epiphyseal-metaphyseal region of long bones in skeletally mature patients, particularly around the knee, distal radius, and sacrum. Despite being classified as benign, GCT has a propensity for local recurrence if inadequately treated and rare potential for malignant transformation or pulmonary metastasis. Treatment typically involves intralesional curettage with adjuvants or en bloc resection for aggressive cases.
Usage
Usage note: Specify anatomical location and distinguish from giant cell-rich lesions of other origins.
In Context
- "The giant cell tumor of the distal radius was treated with curettage and cement reconstruction." — Operative report
- "MRI characteristics of giant cell tumor include T2 hypointense areas due to hemosiderin deposition." — Radiology teaching file