tumor thrombus
A blood clot containing malignant cells that extends from the primary tumor into adjacent blood vessels.
Full Definition
A tumor thrombus represents an extension of malignant tissue into the vascular system, commonly seen in aggressive bone sarcomas. This phenomenon indicates advanced local disease and affects surgical planning, as the thrombus must be completely excised to achieve oncological margins. In orthopedic oncology, tumor thrombi are most frequently encountered in high-grade osteosarcomas and can extend into major vessels such as the femoral or popliteal vessels. The presence of tumor thrombus significantly impacts prognosis and may necessitate vascular reconstruction during tumor resection.
Usage
Usage note: Always hyphenate when used as a compound modifier (tumor-thrombus extension).
In Context
- "Preoperative imaging revealed tumor thrombus extending into the popliteal vein, requiring vascular surgical consultation." — Surgical planning report
- "The pathology report confirmed viable tumor cells within the excised thrombus." — Histopathology report