Bone Morphogenetic Protein
Also written as: BMP — Bone Morphogenetic Protein
Naturally occurring proteins that induce bone and cartilage formation, used therapeutically in orthopedic surgery.
Full Definition
Bone Morphogenetic Proteins (BMPs) are a group of growth factors that play crucial roles in bone development and healing. These proteins stimulate osteoblast differentiation and bone matrix formation, making them valuable therapeutic agents in orthopedic procedures such as spinal fusion and fracture healing enhancement. Recombinant human BMPs (rhBMPs), particularly BMP-2 and BMP-7, are FDA-approved for specific clinical applications. The use of BMPs in clinical practice requires careful documentation of indications, contraindications, and potential complications including inflammatory reactions and ectopic bone formation. Insurance coverage often requires specific documentation of medical necessity.
Usage
Usage note: Specify whether referring to natural BMPs or recombinant human BMPs (rhBMPs) and include specific BMP subtype when applicable.
In Context
- "Bone morphogenetic protein-2 was used as an adjunct to promote fusion in the lumbar spine surgery." — operative report
- "BMP therapy requires monitoring for inflammatory complications and ectopic ossification." — post-operative care protocol