Bone Morphogenetic Protein
Pronunciation: BONE mor-foh-jeh-NET-ik PROH-teen
Naturally occurring growth factors that stimulate bone and cartilage formation.
Full Definition
Bone morphogenetic proteins (BMPs) are a group of naturally occurring signaling molecules that play crucial roles in bone and cartilage development, maintenance, and repair. In orthopedic surgery, recombinant BMPs (particularly BMP-2 and BMP-7) are used as bone graft substitutes or adjuncts to promote bone healing in spinal fusions, nonunions, and other challenging cases. These proteins work by recruiting mesenchymal stem cells and inducing their differentiation into osteoblasts and chondroblasts, thereby enhancing the bone healing process.
Usage
Usage note: Commonly abbreviated as BMP; recombinant forms (rBMP-2, rBMP-7) are used clinically.
In Context
- "Recombinant bone morphogenetic protein was used to enhance fusion rates in this complex revision surgery." — operative report
- "The patient developed heterotopic ossification following BMP-2 application in anterior cervical fusion." — complication report