sepsis
Life-threatening organ dysfunction caused by a dysregulated host response to infection, requiring immediate recognition and treatment in pediatric patients.
Full Definition
Sepsis in children represents a complex syndrome where the body's response to infection causes widespread inflammation and potentially fatal organ dysfunction. Pediatric sepsis differs from adult presentations in several key ways: children may maintain normal blood pressure longer before decompensating, temperature regulation may be impaired, and early signs can be subtle. Recognition relies on age-specific vital sign criteria and clinical assessment tools. Without prompt treatment including antibiotics, fluid resuscitation, and supportive care, sepsis can rapidly progress to septic shock and multi-organ failure.
Usage
Usage note: Distinguished from bacteremia (presence of bacteria in blood) and SIRS (systemic inflammatory response syndrome).
In Context
- "The infant presented with signs of early sepsis including fever, tachycardia, and lethargy." — Clinical assessment
- "Pediatric sepsis protocols emphasize early antibiotic administration within the first hour of recognition." — Treatment guideline