17-hydroxyprogesterone
Pronunciation: seventeen hye-drok-see-pro-JESS-ter-own
Also written as: 17-OHP — 17-hydroxyprogesterone
Steroid hormone precursor elevated in congenital adrenal hyperplasia, particularly 21-hydroxylase deficiency.
Full Definition
A steroid hormone intermediate in the cortisol synthesis pathway that becomes markedly elevated when the 21-hydroxylase enzyme is deficient. This compound serves as the primary biomarker for diagnosing congenital adrenal hyperplasia, particularly the most common 21-hydroxylase deficiency form. Elevated levels indicate a block in cortisol production, leading to accumulation of precursors and shunting toward androgen synthesis. Normal values vary significantly by age, sex, and pubertal status, with special considerations for premature infants who may have physiologically elevated levels. The measurement is performed via immunoassay or liquid chromatography-mass spectrometry for greater specificity.
Usage
Usage note: Use the abbreviated form 17-OHP in routine clinical documentation.
In Context
- "The 17-hydroxyprogesterone level was markedly elevated at 485 ng/dL, confirming CAH diagnosis." — Laboratory report
- "Monitoring 17-hydroxyprogesterone levels helps assess treatment adequacy in CAH patients." — Clinical management guideline