ACTH stimulation test
Also written as: ACTH — Adrenocorticotropic Hormone
Diagnostic test using synthetic adrenocorticotropic hormone to evaluate adrenal cortex function and diagnose adrenal insufficiency.
Full Definition
The ACTH stimulation test, also known as the cosyntropin test, involves administering synthetic adrenocorticotropic hormone (cosyntropin) to assess the adrenal glands' ability to produce cortisol. This test is used to diagnose primary adrenal insufficiency (Addison's disease) and to evaluate secondary adrenal insufficiency. A normal response involves a significant rise in cortisol levels within 30-60 minutes of ACTH administration. The test can be performed as a standard-dose or low-dose protocol depending on the clinical indication and patient age.
Usage
Usage note: Specify dose protocol (standard vs. low-dose) when documenting test results.
In Context
- "The ACTH stimulation test revealed an inadequate cortisol response, confirming primary adrenal insufficiency." — Laboratory interpretation
- "A low-dose ACTH stimulation test was performed to evaluate for secondary adrenal insufficiency." — Procedure note