growth hormone deficiency
Condition characterized by inadequate production of growth hormone, resulting in poor linear growth and short stature.
Full Definition
Growth hormone deficiency (GHD) is an endocrine disorder caused by inadequate secretion of growth hormone by the anterior pituitary gland. It can be congenital (present from birth) or acquired (developing later due to tumors, infections, or trauma). Children with GHD typically present with significantly reduced growth velocity, short stature (usually more than 2-3 standard deviations below the mean), delayed bone age, and characteristic facial features including a prominent forehead and immature appearance. Diagnosis involves growth hormone stimulation testing, and treatment consists of daily growth hormone injections. Early diagnosis and treatment are crucial for optimizing final adult height. GHD may be isolated or part of multiple pituitary hormone deficiencies.
Usage
Usage note: Distinguish from other causes of short stature; may be abbreviated as GHD in subsequent references.
In Context
- "Growth hormone deficiency was confirmed through stimulation testing with peak levels below 10 ng/mL." — Diagnostic workup report
- "The patient's growth velocity improved significantly after starting growth hormone deficiency treatment." — Treatment response evaluation