lipodystrophy
Pronunciation: li-poh-DIS-truh-fee
Group of disorders characterized by selective loss of adipose tissue, often associated with insulin resistance and metabolic complications.
Full Definition
Lipodystrophy encompasses a heterogeneous group of disorders characterized by the selective absence or loss of adipose tissue from various body regions. These conditions can be congenital or acquired, generalized or partial. Congenital generalized lipodystrophy (Berardinelli-Seip syndrome) and familial partial lipodystrophy are genetic forms, while acquired forms may result from autoimmune processes or medications. The loss of subcutaneous fat leads to ectopic fat deposition, severe insulin resistance, diabetes, hypertriglyceridemia, and hepatic steatosis. Management focuses on metabolic complications including diabetes and dyslipidemia.
Usage
Usage note: Specify type (congenital/acquired, generalized/partial) when documenting cases.
In Context
- "The patient's generalized lipodystrophy was associated with severe insulin resistance requiring high-dose insulin therapy." — Clinical assessment
- "Partial lipodystrophy with lower extremity fat loss and upper body fat accumulation was observed." — Physical examination findings