SHBG
Also written as: SHBG — Sex Hormone-Binding Globulin
Plasma protein that binds and transports sex hormones, affecting their bioavailability.
Full Definition
Sex Hormone-Binding Globulin (SHBG) is a glycoprotein produced primarily by the liver that binds testosterone, dihydrotestosterone, and estradiol with high affinity. It serves as the major transport protein for sex hormones in circulation and regulates their bioavailability to target tissues. SHBG levels are influenced by various factors including age, sex, insulin, thyroid hormones, and liver function. In pediatric endocrinology, SHBG measurements help assess androgen status and can be particularly useful in evaluating hyperandrogenism in adolescent girls. Low SHBG levels are associated with insulin resistance and metabolic dysfunction.
Usage
Usage note: Often used to calculate free androgen index; spell out on first use.
In Context
- "Low SHBG levels in this adolescent suggest insulin resistance despite normal glucose tolerance." — Endocrinology clinic note
- "The free androgen index was calculated using total testosterone and SHBG values." — Laboratory report