ganglion cells
Nerve cell bodies in the enteric nervous system whose absence defines Hirschsprung disease.
Full Definition
Ganglion cells are nerve cell bodies that form part of the enteric nervous system, located within the submucosal (Meissner's) and myenteric (Auerbach's) plexuses of the bowel wall. These cells are essential for normal intestinal motility and the coordination of peristalsis. The congenital absence of ganglion cells in a segment of bowel defines Hirschsprung disease, leading to functional obstruction and requiring surgical intervention. Histopathological identification of ganglion cells is the gold standard for diagnosing or excluding Hirschsprung disease. Editors should ensure consistent terminology when describing these cells in medical documentation.
Usage
Usage note: Always plural when referring to multiple cells; distinguish from nerve fibers.
In Context
- "Normal ganglion cells were identified in the submucosal plexus." — Histopathology report
- "The absence of ganglion cells confirmed the diagnosis of Hirschsprung disease." — Pathology consultation