hepatoblastoma
The most common primary liver tumor in children, typically occurring in infants and young children.
Full Definition
Hepatoblastoma is a rare but aggressive primary liver malignancy that represents the most common hepatic tumor in the pediatric population, with peak incidence in children under three years of age. The tumor arises from embryonic liver cells and may present as an abdominal mass, often accompanied by elevated alpha-fetoprotein levels. Risk factors include low birth weight, familial adenomatous polyposis, and Beckwith-Wiedemann syndrome. Treatment typically involves surgical resection, often requiring partial hepatectomy, and may include chemotherapy. The prognosis has improved significantly with modern treatment protocols, particularly for patients with completely resectable tumors.
Usage
Usage note: Distinguished from hepatocellular carcinoma by age of presentation and histology.
In Context
- "The elevated AFP level and imaging findings were consistent with hepatoblastoma." — Oncology consultation
- "Complete surgical resection of the hepatoblastoma was achieved with a right hepatectomy." — Operative report