SCID
Also written as: SCID — Severe Combined Immunodeficiency
Severe Combined Immunodeficiency, a group of rare genetic disorders causing profound immune system dysfunction in infants.
Full Definition
Severe Combined Immunodeficiency (SCID) represents a heterogeneous group of primary immunodeficiency disorders characterized by severely impaired T-cell and often B-cell function. Affected infants typically present within the first few months of life with recurrent, severe infections and failure to thrive. Without treatment, typically bone marrow transplantation or gene therapy, SCID is usually fatal within the first two years of life. The condition affects approximately 1 in 40,000 to 100,000 births and requires immediate medical intervention.
Usage
Usage note: Always capitalize when using the acronym; may be written as 'SCID' or 'severe combined immunodeficiency' in full form.
In Context
- "The patient was diagnosed with SCID following abnormal newborn screening results and subsequent lymphocyte enumeration." — Clinical case report
- "Hematopoietic stem cell transplantation remains the gold standard treatment for SCID." — Treatment protocol