Intermediate
Technical
IVT
thymic hypoplasia
Underdevelopment or reduced size of the thymus gland, often associated with T-cell immunodeficiency.
Full Definition
Thymic hypoplasia refers to the incomplete development or abnormally small size of the thymus gland, which is crucial for T-cell maturation. This condition can be primary (genetic) or secondary (due to infections, medications, or other causes). In pediatric patients, thymic hypoplasia often presents with recurrent infections, failure to thrive, and increased susceptibility to opportunistic pathogens due to impaired T-cell function. It may be part of various genetic syndromes or occur as an isolated finding.
Usage
Usage note: Distinguish from thymic aplasia (complete absence) and normal thymic involution with age.
In Context
- "Chest imaging revealed thymic hypoplasia consistent with the patient's T-cell lymphopenia." — Radiology report
- "The degree of thymic hypoplasia correlated with the severity of immunodeficiency symptoms." — Clinical correlation
Also known as
thymic dysplasia
small thymus
Contrasted with
thymic hyperplasia
Don't confuse with
thymic aplasia
thymic involution