Henoch-Schönlein purpura
Pronunciation: HEN-okh SHERN-line
A small-vessel vasculitis causing characteristic purpuric rash on the lower extremities, often accompanied by arthritis, abdominal pain, and nephritis.
Full Definition
Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children, typically affecting those aged 2-10 years. It presents with a characteristic palpable purpuric rash predominantly on the lower extremities and buttocks, often accompanied by arthritis affecting large joints, crampy abdominal pain that may mimic acute abdomen, and nephritis ranging from microscopic hematuria to nephritic syndrome. The condition is often preceded by an upper respiratory tract infection and is generally self-limiting, though renal involvement may require long-term monitoring. The diagnosis is primarily clinical, supported by the presence of IgA deposits on skin biopsy.
Usage
Usage note: Often abbreviated as HSP; hyphen is preferred in Henoch-Schönlein but may appear without in some texts.
In Context
- "The child's Henoch-Schönlein purpura required serial urinalyses to monitor for renal involvement." — Pediatric nephrology follow-up
- "The palpable purpura on the legs and buttocks was characteristic of Henoch-Schönlein purpura." — Dermatology consultation note