toxic shock-like syndrome
Severe systemic inflammatory response syndrome caused by bacterial superantigens, presenting with fever, rash, and multiorgan dysfunction in pediatric patients.
Full Definition
Toxic shock-like syndrome (TSLS) is a rare but potentially fatal condition in children caused by bacterial superantigens, most commonly from Group A Streptococcus or Staphylococcus aureus. The syndrome is characterized by acute onset of high fever, diffuse erythematous rash, hypotension, and evidence of multiorgan dysfunction including renal, hepatic, or cardiac involvement. Unlike classic toxic shock syndrome, TSLS may occur without the typical desquamation pattern and can present in association with various bacterial infections including pneumonia, cellulitis, or necrotizing fasciitis. Early recognition and aggressive supportive care with antibiotics and intravenous immunoglobulin are crucial for survival.
Usage
Usage note: Distinguish from classic toxic shock syndrome by clinical presentation and underlying pathogen; may be confused with other systemic inflammatory conditions.
In Context
- "The constellation of fever, rash, and hypotension raised concern for toxic shock-like syndrome." — Pediatric intensive care unit note
- "IVIG was administered due to suspected toxic shock-like syndrome secondary to invasive group A streptococcal infection." — Treatment plan