renal biopsy
Percutaneous or surgical sampling of kidney tissue for histopathological examination to diagnose glomerular, tubular, or interstitial diseases.
Full Definition
Renal biopsy is a diagnostic procedure involving obtaining kidney tissue samples for microscopic examination using light microscopy, immunofluorescence, and electron microscopy. In pediatric nephrology, indications include unexplained proteinuria, hematuria with decreased kidney function, rapidly progressive glomerulonephritis, or steroid-resistant nephrotic syndrome. The procedure is typically performed under ultrasound guidance using a percutaneous approach, though open surgical biopsy may be required in young children or those with bleeding disorders. Adequate tissue sampling requires obtaining at least 10-15 glomeruli for accurate diagnosis.
Usage
Usage note: Specify the approach (percutaneous vs. open) and ensure adequate sample size for diagnostic accuracy.
In Context
- "Renal biopsy revealed focal segmental glomerulosclerosis as the cause of steroid-resistant nephrotic syndrome." — Pathology report
- "The decision to proceed with renal biopsy was made after 6 weeks of steroid non-responsiveness." — Clinical decision note