Intermediate
Technical
IVT
tubular dysfunction
Impaired function of kidney tubules affecting electrolyte balance, acid-base status, or concentration ability. Common in pediatric genetic nephropathies.
Full Definition
Tubular dysfunction refers to defective renal tubular transport processes that can affect sodium, potassium, phosphate, glucose, amino acids, or other substances normally reabsorbed or secreted by tubular cells. In pediatric nephrology, this often manifests as isolated defects like renal tubular acidosis or complex syndromes like Fanconi syndrome. The dysfunction may be inherited or acquired and can significantly impact growth and development in children.
Usage
Usage note: Distinguish from acute tubular necrosis, which is cell death rather than dysfunction.
In Context
- "The child presented with growth failure and tubular dysfunction affecting phosphate reabsorption." — Pediatric nephrology consultation
- "Genetic testing confirmed hereditary tubular dysfunction as the cause of recurrent kidney stones." — Clinical genetics report
Also known as
tubulopathy
tubular defect
Contrasted with
normal tubular function
Don't confuse with
glomerular dysfunction
tubular necrosis