alternating hemiplegia of childhood
Also written as: AHC — Alternating hemiplegia of childhood
A rare neurological disorder characterized by recurrent episodes of paralysis affecting either side of the body, often triggered by stress or fatigue.
Full Definition
Alternating hemiplegia of childhood (AHC) is a rare neurodevelopmental disorder characterized by recurrent episodes of hemiplegia that can affect either side of the body and may alternate between sides. Episodes typically begin before 18 months of age and can be triggered by physical or emotional stress, bright lights, water exposure, or fatigue. During attacks, children may experience weakness, dystonia, or complete paralysis of one side of the body. Between episodes, children often show developmental delays, intellectual disability, and movement disorders. Most cases are caused by mutations in the ATP1A3 gene.
Usage
Usage note: Often abbreviated as AHC; most cases due to ATP1A3 mutations; distinguish from hemiplegic migraine by age of onset and features.
In Context
- "The toddler's episodes of alternating weakness were consistent with alternating hemiplegia of childhood." — Pediatric movement disorders clinic
- "ATP1A3 mutation testing confirmed the diagnosis of alternating hemiplegia of childhood." — Genetic counseling report