cerebrospinal fluid analysis
Pronunciation: ser-EE-broh-SPY-nal FLOO-id uh-NAL-ih-sis
Also written as: CSF analysis — cerebrospinal fluid analysis
Laboratory examination of fluid surrounding the brain and spinal cord obtained via lumbar puncture.
Full Definition
Cerebrospinal fluid analysis involves laboratory examination of CSF obtained through lumbar puncture to diagnose various neurological conditions. In pediatric neurology, CSF analysis is crucial for detecting infections (meningitis, encephalitis), inflammatory conditions, metabolic disorders, and malignancies affecting the central nervous system. Key parameters include cell count and differential, protein levels, glucose concentration, opening pressure, and specialized tests like oligoclonal bands, lactate, or pathogen-specific PCR. Normal values differ significantly between neonates, infants, and older children, requiring age-appropriate reference ranges for accurate interpretation.
Usage
Usage note: Always specify age-appropriate normal values. Include opening pressure when clinically relevant.
In Context
- "CSF analysis revealed pleocytosis with lymphocytic predominance, suggesting viral encephalitis." — Laboratory report interpretation
- "The lumbar puncture yielded clear CSF with normal pressure and cell count, ruling out bacterial meningitis." — Emergency department procedure note