FIRES
Pronunciation: FY-ers
Also written as: FIRES — Febrile Infection-Related Epilepsy Syndrome
Febrile infection-related epilepsy syndrome, a rare condition where previously healthy children develop refractory status epilepticus following a febrile illness.
Full Definition
FIRES is a devastating condition affecting previously healthy children who develop super-refractory status epilepticus following a nonspecific febrile illness. The seizures are extremely difficult to control despite multiple antiepileptic medications and anesthetic agents. The condition has a poor prognosis with high mortality and morbidity rates, often resulting in severe cognitive impairment in survivors. The pathophysiology is poorly understood, and treatment remains largely supportive with aggressive seizure management.
Usage
Usage note: Capitalize as acronym. Extremely rare but important to recognize for urgent management.
In Context
- "The previously healthy 8-year-old developed FIRES following a viral prodrome." — ICU admission note
- "Despite multiple therapeutic interventions, the FIRES case remained refractory to treatment." — Case conference