responsive neurostimulation
Pronunciation: ri-SPON-siv NOOR-oh-stim-yuh-LAY-shun
Also written as: RNS — responsive neurostimulation
Implantable device that detects seizure activity and delivers targeted electrical stimulation to interrupt seizures.
Full Definition
Responsive neurostimulation (RNS) represents a closed-loop neurostimulation system that continuously monitors brain activity through implanted electrodes and delivers targeted electrical stimulation when seizure patterns are detected. Unlike VNS, which provides continuous or scheduled stimulation, RNS responds only to detected abnormal activity. The system consists of a neurostimulator implanted in the skull and depth or subdural electrodes placed directly in or on the seizure focus. While approved for adults, RNS is increasingly used off-label in adolescent patients with localized, medication-resistant epilepsy who are not surgical candidates.
Usage
Usage note: Currently FDA-approved only for adults but used off-label in adolescents. Requires specialized epilepsy monitoring capabilities.
In Context
- "RNS therapy was considered for the 16-year-old with bitemporal seizure onset." — Presurgical evaluation summary
- "The RNS device recorded 47 electrographic seizures over the past month, with 23 requiring stimulation." — Device interrogation report