Favourable Histology
A formal INPC designation applied to neuroblastic tumours whose histopathological features—including tumour category, degree of differentiation, and mitosis–karyorrhexis index—predict a relatively good prognosis.
Full Definition
In the context of the International Neuroblastoma Pathology Classification, 'favorable histology' (FH) is a precisely defined prognostic designation, not a general qualitative descriptor. A neuroblastic tumour is classified as FH based on a combination of its histological subtype, the degree of Schwannian stromal development, grade of neuroblastic differentiation, mitosis–karyorrhexis index (MKI), and patient age. FH tumours are associated with better outcomes and may qualify for less intensive therapy within COG protocols. Editors must not use 'favorable histology' as a vague synonym for 'good-looking tumour' or apply it outside the neuroblastic tumour context without qualification. Its antonym, 'unfavourable histology,' carries specific clinical weight and must likewise be used only in its formal sense.
Usage
Usage note: A formal INPC term: do not paraphrase, substitute synonyms, or apply outside the neuroblastic tumour classification context. Note British/Australian spelling 'favorable' vs American 'favorable'; standardize to house style.
In Context
- "The final pathology report classified the adrenal mass as ganglioneuroblastoma, intermixed type, with favorable histology per INPC criteria." — Pediatric oncology pathology report
- "The term 'favorable histology' in this context is an INPC-specific technical designation and should not be altered to 'good prognosis histology' by copy editors." — Editorial annotation