INPC
Also written as: INPC — International Neuroblastoma Pathology Classification
The International Neuroblastoma Pathology Classification; a standardised histopathological grading system for peripheral neuroblastic tumours based on the Shimada classification.
Full Definition
The International Neuroblastoma Pathology Classification (INPC), an evolution of the Shimada system, categorises peripheral neuroblastic tumours into neuroblastoma, ganglioneuroblastoma intermixed, ganglioneuroblastoma nodular, and ganglioneuroma based on histological features including Schwannian stromal content, degree of neuroblastic differentiation, mitosis–karyorrhexis index (MKI), and patient age. Each tumour is assigned a favourable or unfavourable histological designation that is a key input into paediatric oncology risk-stratification algorithms. Accurate transcription of the MKI category (low, intermediate, or high) and differentiation subtype in pathology reports is essential; editorial errors in these fields can directly affect treatment intensity decisions.
Usage
Usage note: Do not confuse INPC (histopathological classification) with INRG (risk-group stratification system); they serve related but distinct purposes in neuroblastoma management.
In Context
- "Per INPC criteria, the tumour was classified as neuroblastoma, poorly differentiated, with a high mitosis–karyorrhexis index and unfavourable histology." — Pediatric oncology pathology report
- "The editor confirmed that 'INPC' and 'INRG' had been used interchangeably in the manuscript and requested author clarification." — Manuscript review note