LCH
Also written as: LCH — Langerhans Cell Histiocytosis
Acronym for Langerhans Cell Histiocytosis, a clonal myeloid neoplasm involving CD1a/CD207-positive Langerhans cells.
Full Definition
LCH is the standard abbreviation for Langerhans Cell Histiocytosis, used throughout pediatric pathology, oncology, and radiology literature after the full form has been established on first mention. The acronym appears in staging documents, multidisciplinary team reports, treatment protocols (notably those from the Histiocyte Society), and pathology synoptic summaries. Editors must expand LCH to its full form at first occurrence in any document and should not confuse it with other histiocytic acronyms such as HLH (haemophagocytic lymphohistiocytosis) or RDD (Rosai–Dorfman disease). In pediatric pathology contexts, LCH is always capitalised and is not pluralised.
Usage
Usage note: Always expand on first use; do not capitalise mid-sentence as a common noun.
In Context
- "The diagnosis of LCH was confirmed by immunohistochemistry demonstrating strong CD1a and langerin positivity." — Pathology report
- "The protocol requires that LCH be expanded to Langerhans cell histiocytosis on first mention in all submitted manuscripts." — Journal submission guidelines