Wilson-Mikity syndrome
Rare chronic lung disease of prematurity characterized by progressive pulmonary deterioration without initial respiratory distress.
Full Definition
Wilson-Mikity syndrome is a rare form of chronic lung disease affecting very low birth weight premature infants, characterized by insidious onset of respiratory symptoms typically appearing weeks after birth. Unlike typical bronchopulmonary dysplasia, affected infants initially have minimal or no respiratory distress but later develop progressive tachypnea, oxygen dependence, and feeding difficulties. Chest radiographs show characteristic coarse, streaky infiltrates progressing to hyperinflation and cystic changes. The pathophysiology involves abnormal alveolar development and may be related to inflammatory processes, though the exact etiology remains unclear.
Usage
Usage note: Rare condition; distinguish from more common bronchopulmonary dysplasia by timing and presentation pattern.
In Context
- "The extremely premature infant developed Wilson-Mikity syndrome at six weeks of age despite an initially benign respiratory course." — Specialty consultation report
- "Radiographic findings of bilateral streaky infiltrates and hyperinflation supported the diagnosis of Wilson-Mikity syndrome." — Diagnostic imaging interpretation