drug-induced lupus
A lupus-like syndrome triggered by certain medications, typically reversible upon drug discontinuation in pediatric patients.
Full Definition
Drug-induced lupus is a syndrome that mimics systemic lupus erythematosus but is triggered by exposure to specific medications. In children, the most commonly implicated drugs include anti-TNF agents (used for inflammatory arthritis), anticonvulsants, and certain antibiotics. The condition typically presents with systemic symptoms such as fever, arthritis, and serositis, but is less likely to involve kidneys or central nervous system compared to idiopathic lupus. Laboratory findings often include positive antinuclear antibodies and anti-histone antibodies, while anti-dsDNA antibodies are usually negative. The syndrome is generally reversible upon discontinuation of the offending medication, though resolution may take weeks to months.
Usage
Usage note: Emphasize reversibility and temporal relationship to drug exposure; distinguish from lupus flare.
In Context
- "The temporal relationship between etanercept initiation and lupus-like symptoms suggested drug-induced lupus." — Clinical assessment
- "Anti-histone antibodies were positive, supporting the diagnosis of drug-induced lupus rather than idiopathic disease." — Laboratory interpretation