methotrexate intolerance
A clinical syndrome involving gastrointestinal and behavioral symptoms that develop in pediatric patients receiving methotrexate therapy.
Full Definition
Methotrexate intolerance is a well-recognized complication in pediatric rheumatology characterized by anticipatory nausea, vomiting, abdominal pain, and behavioral avoidance symptoms that develop in children receiving methotrexate treatment. This condition can significantly impact treatment adherence and quality of life, often necessitating route changes from oral to subcutaneous administration or complete medication substitution. The syndrome appears to have both physiological and psychological components, with some patients developing symptoms even before medication administration. Recognition and management of methotrexate intolerance is crucial for maintaining effective disease control in pediatric rheumatic conditions.
Usage
Usage note: Distinguish from 'methotrexate toxicity' which refers to organ-specific adverse effects rather than intolerance symptoms.
In Context
- "The patient developed significant methotrexate intolerance, requiring transition to subcutaneous administration." — Treatment modification note
- "Antiemetic premedication was prescribed to manage methotrexate intolerance symptoms." — Prescription rationale