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biliary atresia
Pronunciation: BIL-ee-air-ee ah-TREE-zhah
Progressive inflammatory condition causing obstruction or absence of bile ducts in newborns.
Full Definition
A serious liver condition affecting newborns, characterized by inflammation and progressive destruction of the bile ducts outside and inside the liver. This results in bile flow obstruction, leading to liver damage and potentially life-threatening complications if untreated. Early recognition and surgical intervention (Kasai procedure) within the first 60-90 days of life are critical for optimal outcomes. The condition is the most common indication for liver transplantation in children.
Usage
Usage note: Emphasize timing of intervention; distinguish from other causes of neonatal cholestasis.
In Context
- "The infant's persistent jaundice and acholic stools raised suspicion for biliary atresia." — gastroenterology consultation
- "Hepatobiliary scintigraphy confirmed the diagnosis of biliary atresia requiring urgent Kasai procedure." — surgical planning note
Also known as
extrahepatic biliary atresia
Don't confuse with
choledochal cyst
neonatal hepatitis
Alagille syndrome