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fetal fibronectin
Protein marker used to predict risk of preterm delivery when detected in cervical secretions.
Full Definition
A glycoprotein that acts as an adhesive between the fetal membranes and the maternal decidua. Fetal fibronectin (fFN) testing involves collecting cervicovaginal secretions to detect this protein, which is normally absent between 22-34 weeks of pregnancy. A positive fFN test indicates disruption of the maternal-fetal interface and suggests increased risk of preterm delivery within 7-14 days. However, a negative test is more clinically useful, as it has a high negative predictive value for preterm delivery.
Usage
Usage note: Often abbreviated as 'fFN' in clinical documentation. Note the lowercase 'f' in the abbreviation.
In Context
- "The negative fetal fibronectin test provided reassurance about preterm delivery risk." — Prenatal care documentation
- "Fetal fibronectin testing should not be performed if there has been recent sexual activity." — Laboratory collection protocol
Also known as
fFN
Don't confuse with
ferritin
fibrinogen