Intermediate Technical IVT

gene panel testing

Targeted sequencing of a predefined set of cancer-relevant genes to detect clinically significant alterations.

Full Definition

Gene panel testing is a focused molecular diagnostic approach that analyzes a curated subset of genes known to be relevant for cancer diagnosis, prognosis, or treatment selection. Unlike whole exome or genome sequencing, panel testing concentrates on genes with established clinical significance, typically ranging from dozens to hundreds of targets. Panels may be designed for specific cancer types, therapeutic classes, or clinical applications such as hereditary cancer predisposition. This approach balances comprehensive coverage of relevant genes with practical considerations including turnaround time, cost, and data interpretation complexity. Modern cancer gene panels often include hotspot regions, full gene coverage for tumor suppressors, and copy number analysis.

Usage

Usage note: Specify panel size and focus when first mentioned in documents

In Context

"The 400-gene panel testing revealed multiple alterations suitable for targeted therapy." — Molecular pathology report
"Gene panel testing provides comprehensive coverage while maintaining clinically relevant turnaround times." — Laboratory service description

Also known as

targeted gene panel cancer gene panel panel sequencing

Contrasted with

whole genome sequencing single gene testing

Don't confuse with

gene expression profiling chromosomal microarray FISH testing

fusion gene ← Back to glossary germline variant