HRD score
A genomic assay score measuring homologous recombination deficiency to predict PARP inhibitor sensitivity.
Full Definition
The homologous recombination deficiency score is a numerical assessment that quantifies genomic instability patterns indicative of defective DNA repair mechanisms. The score incorporates multiple genomic signatures including loss of heterozygosity, large-scale state transitions, and telomeric allelic imbalance. Higher HRD scores suggest greater genomic instability and potential responsiveness to DNA-damaging agents or PARP inhibitors. This biomarker has become crucial in treatment selection for ovarian, breast, and prostate cancers, where HRD-positive tumors may benefit from specific targeted therapies regardless of BRCA mutation status.
Usage
Usage note: Always specify the assay platform when citing HRD scores
In Context
- "The tumor's HRD score of 42 exceeded the threshold for PARP inhibitor eligibility." — Molecular pathology report
- "Patients with high HRD scores demonstrated improved progression-free survival on olaparib." — Clinical trial publication