pathway-directed therapy
Treatment approach targeting specific molecular signaling cascades rather than individual gene mutations.
Full Definition
Pathway-directed therapy represents a strategic approach to cancer treatment that targets entire molecular signaling cascades rather than focusing on individual genetic alterations. This therapeutic strategy recognizes that cancer cells often activate alternative pathway components to bypass single-target inhibition, necessitating broader pathway-level intervention. Pathway-directed approaches may involve combination therapies targeting multiple pathway nodes, drugs that inhibit pathway hubs, or agents that disrupt essential pathway functions. Clinical implementation requires comprehensive understanding of pathway biology, robust biomarker strategies, and careful management of combination therapy toxicities.
Usage
Usage note: Hyphenate compound modifier; emphasize pathway-level rather than gene-level targeting.
In Context
- "Pathway-directed therapy using PI3K/mTOR dual inhibition showed promising activity in this patient cohort." — Clinical trial manuscript
- "The oncologist recommended pathway-directed therapy targeting the DNA damage response pathway." — Treatment planning note