Professional
Technical
IVT
PDL1
Pronunciation: P-D-L-one
Also written as: PDL1 — Programmed Death-Ligand 1
Programmed death-ligand 1, a protein biomarker used to predict immunotherapy response.
Full Definition
Programmed death-ligand 1 is a transmembrane protein that serves as a key checkpoint inhibitor target and predictive biomarker in cancer immunotherapy. PD-L1 expression levels on tumor cells and tumor-infiltrating immune cells help guide treatment decisions for immune checkpoint inhibitors. Various scoring systems and antibody clones create complexity in interpretation and require careful attention to methodology and cutoff values.
Usage
Usage note: Can be written as PD-L1 or PDL1. Maintain consistency within documents.
In Context
- "PDL1 expression by immunohistochemistry was 65% using the 22C3 antibody clone." — Biomarker report
- "The patient's low PDL1 expression suggested limited benefit from single-agent immunotherapy." — Treatment planning note
Also known as
PD-L1
programmed death-ligand 1
Contrasted with
PD-1
checkpoint activator
Don't confuse with
PD-1
LAG-3
CTLA-4