targetable alteration
Genetic variant with available FDA-approved or investigational therapies that specifically address the molecular abnormality.
Full Definition
A targetable alteration is a specific genetic variant, gene fusion, or molecular abnormality for which effective targeted therapeutic agents exist or are in clinical development. These alterations include oncogenic mutations, gene amplifications, and chromosomal rearrangements that drive cancer growth and can be specifically inhibited by small molecules, monoclonal antibodies, or other precision therapies. The determination of targetability depends on current therapeutic options, clinical evidence, and regulatory approval status. Clinical reports must clearly distinguish between targetable alterations with established therapies versus those with experimental treatments.
Usage
Usage note: Preferred over 'actionable' in clinical documentation; specify therapy availability level when possible.
In Context
- "Genomic testing identified three targetable alterations including an EGFR exon 19 deletion." — Molecular tumor board report
- "The patient's tumor harbored no targetable alterations based on current therapeutic options." — Precision oncology consultation